Endocrine Abstracts

Context: The genes implicated in premature ovarian failure play a role in crucial biologic processes such as DNA repair, meiosis, germ cell recruitment, steroidogenesis and mitochondrial function. Mitochondrial disorders are varied in their onset, inheritance pattern, and clinical presentation, but they often cause dysfunction in organs with high energy demands. Frequent features include hypertrophic cardiomyopathy, heart conduction defects, myopathy, sensorineural deafness, c...